Salivary Gland Adenoid Cystic Carcinoma is Promoted by Increased POFUT1 Expression

Previous studies have reported the up-regulated expression of protein O-fucosyltransferase 1 (POFUT1) in several human malignant tumors. This study purposes to explore relevance POFUT1 clinical and biological characteristics salivary gland adenoid cystic carcinoma (SACC). 54 SACC samples were applied immunohistochemistry evaluate practical POFUT1. The cells from submandibular (HSG), cell lines (SACC-83, SACC-LM) quantitative PCR Western blots confirm elevated SACC. shRNA delivered into knock down expression, then, capacities progressing, proliferating, colony forming surviving evaluated. patients found exhibiting a noticeably robuster compared noncancerous samples. Statistical analysis indicated significant correlation T classification Similarly, was also normal gland. decreased remarkably suppressed proliferation, amount survival. Therefore, enhances proliferation survival SACC, which implicates that could be used as an index for prognosis potential target future therapy.